David Cassuto is the grandson of Umberto Cassuto.
The son of Umberto Cassuto, Nathan Cassuto, was also a rabbi in Florence. He perished in the Nazi death camps. Nathans children have been saved and they emigrated with their mother to Israel. One of the Nathans children is David Cassuto (1938), who became an architect, played an important role in rebuilding the jewish quarter in the old city of Jerusalem.
In the nineties he was for some years vice mayor of Jerusalem.